Name Jan Rainer Kassubek
Geburtsdatum: 12. Februar 1969


Akademische Ausbildung:

10/1988 bis 05/1995 Studium der Humanmedizin an der Universität Essen
02/1997 Promotion zum Dr. med.
10/2004 Habilitaion für das Fach Neurologie (Titel:"Zerebrale Topik und Funktion bei Basalganglienerkrankungen und fokalen Kortexveränderungen: Standardisiertes multimodales Bildgebungskonzept")
10/2005 Leiter der Sektion Neurophysiologie
02/2007 außerplanmäßiger Professor für Neurologie


Klinische Ausbildung:

06/1995 bis 09/1996 Neurologische Universitätsklinik Erlangen
09/1996 bis 12/1996 Forschungsaufenthalt am Center for Magnetic Resonance Research der University of Minnesota
01/1997 bis 08/2001 Neurologische Universitätsklinik Freiburg
08/2001 bis 08/2002 Psychatrische Klinik III der Universität Ulm
seit 08/2002 Neurologische Universitätsklinik Ulm
01/2003 Facharzt für Neurologie
02/2003 Oberarzt der Neurologischen Klinik der Universität Ulm
seit 12/2004 Leitender Oberarzt der Neurologischen Klinik der Universität Ulm, RKU


Aktuelle Position und Funktionen: 

  • Leitender Oberarzt der Neurologischen Klinik der Universität Ulm, RKU und Stellvertreter des Ärztlichen Dirktors
  • Leiter der Sektion Neurophysiologie der Neurologischen Klinik der Universität Ulm
  • Leiter der Arbeitsgruppe für Bildgebung, Neurologische Universitätsklinik Ulm
  • Leiter der Spezialambulanz für Bewegungsstörungen, Neurologische Universitätsklinik Ulm
  • Leiter der Spezialambulanz für HSP, Neurologische Universitätsklinik Ulm

Originalarbeiten und Short Communications in Peer-reviewed Journals:

1.      O. Witzke, J. Kassubek, E. Bonmann, E. Musch: ”Cryoglobulinemia, a complication of infectious disease” (Clinical Investigator (1994); 72: 1048-1050)                                                                                                                       IF: 1,0

2.      J. Kassubek, O. Witzke, E. Bonmann, E. Musch: ”Alternating immune therapy in renal cell carcinoma” (Onkologie (1995); 18: 252-254)      IF: 0,6

3.      C. Stippich, J. Kassubek, P. Sörös, O. Ganslandt, K. Kamada, H. Kober, R. Hopfengärtner, R. Steinmeier, J. Vieth: ”Precise pre- and intraoperative assessment of functional cortex by magnetoencephalography” (Biomedizinische Technik (1996); 41 (Suppl. 1): 306-307)                                                     IF: 0,4

4.      J. Kassubek, C. Stippich, P. Sörös, K. Kamada, H. Kober, R. Hopfengärtner, J. Vieth: ”Magnetoencephalographic findings in patients with multiple sclerosis” (Biomedizinische Technik (1996); 41 (Suppl. 1): 308-309) IF: 0,4

5.      J. Kassubek, C. Stippich, P. Sörös, O. Ganslandt, K. Kamada, R. Hopfengärtner, H. Kober, R. Steinmeier, J. Vieth: ”A motor field source localization protocol using magnetoencephalography” (Biomedizinische Technik (1996); 41 (Suppl. 1): 334-335)                                                    IF: 0,4

6.      S. Engelhardt, W. Zieger, J. Kassubek, M. C. Michel, M. J. Lohse, O.-E. Brodde: ”Tocolytic therapy with fenoterol induces selective downregulation of ß-adrenergic receptors in human myometrium” (Journal of Clinical Endocrinology and Metabolism (1997); 82: 1235-1242)                                                              IF: 5,2

7.      K. Kamada, M. Möller, M. Saguer, J. Kassubek, H. Kober, D. Wenzel, J. Vieth: ”Benign rolandic epilepsy investigated by magnetoencephalography” (Biomedizinische Technik (1997); 42 (Suppl. 1): 185-187)                  IF: 0,4

8.      O. Ganslandt, R. Steinmeier, H. Kober, J. Vieth, J. Kassubek, J. Romstöck, C. Strauss, R. Fahlbusch: ”Magnetic source imaging combined with image-guided frameless stereotaxy: a new method in surgery around the motor strip” (Neurosurgery (1997); 41: 621-628)                                                                     IF: 2,8

9.      K. Kamada, M. Möller, M. Saguer, J. Kassubek, M. Kaltenhäuser, H. Kober, M. Überall, H. Lauffer, D. Wenzel, J. Vieth: ”Localization analysis of neuronal activities in benign rolandic epilepsy using magnetoencephalography” (Journal of the Neurological Sciences (1998); 154: 164-172)                                      IF: 2,0

10. C. Stippich, P. Freitag, J. Kassubek, P. Sörös,  K. Kamada, H. Kober, K. Scheffler, R. Hopfengärtner, D. Bilecen, E.-W. Radü, J. Vieth: ”Motor, somatosensory and auditory cortex localization by fMRI and MEG” (NeuroReport (1998); 9 (9): 1953-1957)                                                                              IF: 2,4

11. D. Lange, S. Aleksic, J. Kassubek, M. M. Vrvic, M. Kist, B. Steinbrückner, M. Mitova: ”Detection of antibodies against Campylobacter jejuni serogroup PEN O:19 purified flagellar protein in a patient with Guillain-Barré syndrome” (International Journal of Medical Microbiology, Virology, Parasitology and Infectious Diseases (1999); 289 (4): 429-444)                                             IF: 0,5

12. F. D. Juengling, J. Kassubek, E. Moser, E. U. Nitzsche: ”Precise localization of dysfunctional areas in vertebro-basilar infarction by FDG- and H215O-PET using standardized image analysis and image registration to 3-D MR” (Nuklearmedizin (1999); 38: 341-344)                                                                                   IF: 1,0

13. J. Kassubek, P. Sörös, H. Kober, C. Stippich, J. B. Vieth: ”Focal slow and beta brain activity in patients with multiple sclerosis revealed by magnetoencephalography” (Brain Topography (1999); 11 (3): 193-200)                                                                                                                                      IF: 1,7

14. J. Kassubek, M. Otte, T. Wolter, M. W. Greenlee, T. Mergner, C. H. Lücking: ”Brain imaging in a patient with hemimicropsia” (Neuropsychologia (1999); 37: 1327-1334)                                                                                          IF: 3,3

15. J. Kassubek, M. Obert, C. H. Lücking: ”Superficial siderosis of the CNS: a late complication of cerebellar tumors” (Neurology (1999); 53 (8): 1893-1894)                                                                                                          IF: 5,2

16. F. D. Juengling, J. Kassubek, A. Otte: ”Standardization of cerebral PET imaging in clinical neurological diagnostics” (European Journal of Nuclear Medicine (2000); 27: 98)                                                                                               IF: 3,5

17. G. Hickok, P. Erhard, J. Kassubek, A. K. Helms-Tillery, S. Naeve-Velguth, J. P. Strupp, P. L. Strick, K. Ugurbil: ”A functional magnetic resonance imaging study of the role of left posterior superior temporal gyrus in speech production: implications for the explanation of conduction aphasia” (Neuroscience Letters (2000); 287 (2): 156-160)                                                                               IF: 2,0

18. J. Kassubek, F. D. Juengling, A. Otte: ”Improved interpretation of cerebral PET with respect to structural MRI changes using combined voxel-based statistical mapping” (European Journal of Nuclear Medicine (2000); 27: 880)

                                                                                                                                 IF: 3,5

19. C. Stippich, J. Kassubek, H. Kober, P. Sörös, J. B. Vieth: ”Time course of focal slow wave activity in transient ischemic attacks and transient global amnesia as measured by magnetoencephalography” (NeuroReport (2000); 11 (15): 3309-3313)                                                                                                       IF: 2,4

20. G. Schumann, U. Halsband, J. Kassubek, S. Gustin, T. Heinks, F. D. Juengling, M. Hüll: ”Combined semantic dementia and apraxia in a patient with frontotemporal lobar degeneration” (Psychiatry Research Neuroimaging (2000); 100 (1): 21-29)                                                                                                         IF: 2,4

21. M. Knauff, J. Kassubek, T. Mulack, M. W. Greenlee: ”Cortical activation evoked by visual mental imagery as measured by functional MRI” (NeuroReport (2000); 11 (18): 3957-3962)                                                                                   IF: 2,4

22. A. Otte, F. D. Juengling, J. Kassubek: ”Exceptional brain function in musicians and the neural basis of music processing” (European Journal of Nuclear Medicine (2001); 28 (1): 130-131)                                          IF:3,5

23. J. Kassubek, F. D. Juengling, E. U. Nitzsche, C. H. Lücking: ”Limbic encephalitis investigated by 18FDG-PET and 3D MRI” (Journal of Neuroimaging (2001); 11 (1): 55-59)                                                IF: 0,9

24. J. Kassubek, K. Schmidtke, H. Kimmig, C. H. Lücking, M. W. Greenlee: ”Changes in cortical activation during mirror reading before and after training: an fMRI study of procedural learning” (Cognitive Brain Research (2001); 10 (3): 207-217)                                                                             IF: 2,9

25. F. D. Juengling, J. Kassubek, S. M. Weiner: ”Cerebral glucose metabolism in Sneddon’s syndrome associated with antiphospholipid antibodies” (Lupus (2001); 10: 309-310)                                                                                                 IF: 1,9

26. J. Kassubek, F. D. Juengling, B. Hellwig, M. Knauff, J. Spreer, C. H. Lücking: ”Hypermetabolism in the ventrolateral thalamus in unilateral Parkinsonian resting tremor: a positron emission tomography study” (Neuroscience Letters (2001); 304 (1-2): 17-20)                                                               IF: 2,0

27. H. Kimmig, M.W. Greenlee, M. Gondan, M. Schira, J. Kassubek, T. Mergner: ”Relationship between saccadic eye movements and cortical activity as measured by fMRI: quantitative and qualitative aspects” (Experimental Brain Research (2001); 141: 184-194)                                                                                     IF: 2,3

28. J. Kassubek, B. Zucker,  E. Oehm, A. Serr, S. M. Arnold, C. H. Lücking, T. Els: ”Tuberculous meningoencephalitis in HIV-seronegative patients: variety of clinical presentation and impact on diagnostics and treatment” (Acta Neurologica Scandinavica (2001); 104 (6): 389-396)           IF: 1,1

29. F. Feuerhake, B. Volk, C. Ostertag, F. D. Juengling, J. Kassubek, M. Orszagh, M. Dichgans: ”Reversible coma with raised intracranial pressure: an unusual clinical manifestation of CADASIL” (Acta Neuropathologica (2002); 103: 188-192)

                                                                                                                                 IF: 2,2

30. T. van Elst, F. D. Juengling, J. Kassubek, K. Schmidtke, T. Thiel, D. Ebert, P. Dykierek, M. Hüll: ”On the role of quantitative brain imaging in the differential diagnosis of speech disorders” (Psychiatry and Clinical Neurosciences (2002); 56: 111-115)                                                                                                    IF: 0,5

31. M. Knauff, T. Mulack, J. Kassubek, H. R. Salih, M. W. Greenlee: ”Spatial imagery of deductive reasoning: a functional MRI study” (Cognitive Brain Research (2002); 13 (2): 203-212)                                                                IF: 2,9

32. J. Kassubek, F. D. Juengling, B. Hellwig, J. Spreer, C. H. Lücking: ”Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging” (Neuroscience Letters (2002); 323 (1): 29-32)           IF: 2,0

33. F. D. Juengling, J. Kassubek, S. Högerle, E. U. Nitzsche, E. Moser: ”SMART-PET (Segmented MRI And Registered Talairach-transformed PET) – multimodality white matter imaging and display without loss of quantitative information” (Journal of Magnetic Resonance Imaging (2002); 15 (4): 456-461)

                                                                                                                                 IF: 2,4

34. E. Oehm, T. Els, J. Spreer, J. Kassubek, A. Hetzel: ”Transcranial color coded sonography in basilar artery stenting” (Ultrasound in Medicine and Biology (2002); 28 (3): 383-387)                                                                                            IF: 1,6

35. J. Kassubek, A.-D. Sperfeld, P. Satrapi, J. Fischer, C. Schönfeldt-Lecuona, B. J. Connemann: ”Klinik und aktuelle Therapie des Gilles-de-la-Tourette-Syndroms” (Nervenheilkunde (2002); 21: 149-155)                         IF: 0,3

36. J. Kassubek, F. D. Juengling, A.-D. Sperfeld, A. Wunderlich, G. Grön: ”Klinische Anwendung bildgebender Diagnostik bei fortgeschrittener frontotemporaler Lobaratrophie: 3D-MR-Morphometrie und PET” (Nervenheilkunde (2002); 21: 214-218)                                                    IF: 0,3

37. J. Spreer, S. Arnold, A. Quiske, R. Wohlfarth, S. Ziyeh, D. Altenmueller, M. Herpers, J. Kassubek, J. Klisch, B. J. Steinhoff, J. Honegger, A. Schulze-Bonhage, M. Schumacher: ”Determination of hemispheric dominance for language: comparison of frontal and temporal fMRI activation with intracarotid amytal testing” (Neuroradiology (2002); 44: 467-474)                                 IF: 1,1

38. J. Kassubek, H.-J. Huppertz, J. Spreer, A. Schulze-Bonhage: ”Detection and localization of focal cortical dysplasia by voxel-based 3-D MRI analysis” (Epilepsia (2002); 43 (6): 596-602)                                                                  IF: 3,3

39. J. Kassubek, F. D. Juengling: ”Results on coregistration of mediotemporal FDG-PET hyperactivity and 3D magnetic resonance imaging hyperintense lesions in limbic encephalitis” (Journal of Neuroimaging (2002); 12 (3): 282-283)                                                                                                           IF: 0,9

40. I. C. Bötefür, J. Kassubek, M. Schumacher: ”Unusually quick resorption of an intracerebral hemorrhage in congenital afibrinogenemia" (Neuroradiology (2002); 44: 912-914)                                                                                                 IF: 1,1

41. T. Els, A. Serr, J. Klisch, E. Oehm, C. H. Lücking, J. Kassubek: ”Tuberkulöse Meningoenzephalitis: Klinisches Bild, Diagnostik und Behandlung” (Medizinische Klinik (2002); 97: 579-587)                                          IF: 0,4

42. F. D. Juengling, J. Kassubek: ”Nuklearmedizinische Bildgebung in der Epilepsiediagnostik I: Perfusion und Metabolismus” (Nervenheilkunde (2002); 21: 420-425)                                                                                  IF: 0,3

43. J. Kassubek, F. D. Juengling: ”Nuklearmedizinische Bildgebung in der Epilepsiediagnostik II: Rezeptordiagnostik und funktionelle Bildgebung” (Nervenheilkunde (2002); 21: 475-481)                                            IF: 0,3

44. C. Schönfeldt-Lecuona, H. Walter, B. J. Connemann, J. Kassubek, M. Spitzer, U. Herwig: ”Geschichte und aktuelle Forschungstrends der antidepressiven repetitiven transkraniellen Magnetstimulation (rTMS)” (Fortschritte der Neurologie und Psychiatrie (2002): 70 (10): 520-530)                                                  IF: 0,6

45. P. Stiller, J. Kassubek, C. Schönfeldt-Lecuona, B. J. Connemann: ”Wilson´s disease in psychiatric patients” (Psychiatry and Clinical Neurosciences (2002); 56: 649)                                                                                                               IF: 0,5

46. F. D. Juengling, J. Kassubek, H. Martens-Le Bouar, M. J. Reinhardt, T. Krause, E. U. Nitzsche, E. Moser, R. Korinthenberg: ”Cerebral regional hypometabolism caused by propofol-induced sedation in children with severe myoclonic epilepsy – a study using fluorodeoxyglucose positron emission tomography and statistical parametric mapping” (Neuroscience Letters (2002); 335 (2): 79-82)        IF: 2,0

47. J. Kassubek, H. Tumani, D. Ecker, A. Kurt, A. C. Ludolph, F. D. Juengling: “Age-related brain parenchymal fraction is significantly decreased in young multiple sclerosis patients: a quantitative MRI study“ (NeuroReport (2003); 14 (3): 427-430)                                                                                                IF: 2,4

48. J. Kassubek, G. B. Landwehrmeyer, C. H. Lücking, F. D. Juengling: “Postischemic Holmes´ tremor investigated by FDG- and H215O-PET“ (Journal of Radiology (2003); 6 (June): 1-8)                                 IF: -

49. J. Kassubek, F. D. Juengling, T. Els, J. Spreer, M. Herpers, T. Krause, E. Moser, C. H. Lücking: “Activation of a residual cortical network during painful stimulation in long-term postanoxic vegetative state: a 15O-H2O PET study“ (Journal of the Neurological Sciences (2003); 212 (1-2): 85-91) IF: 2,0

50. J. Kassubek, F. D. Juengling, S. Hoffmann, A. Rosenbohm, A. Kurt, K. Jurkat-Rott, P. Steinbach, M. Wolf, A. C. Ludolph, F. Lehmann-Horn, H. Lerche, Y. G. Weber: “Quantification of brain atrophy in myotonic dystrophy and proximal myotonic myopathy: a controlled 3-dimensional magnetic resonance imaging study“ (Neuroscience Letters (2003); 348 (2): 73-76)                                                                                                                                 IF: 2,0

51. F. D. Juengling, J. Kassubek: “Standardized calculation of brain parenchymal fraction: an approach to objective assessment of cerebral atrophy” (American Journal of Neuroradiology (2003); 24: 1492-1493) IF: 2,2

52. M. Wilke, J. Kassubek, S. Ziyeh, A. Schulze-Bonhage, H.-J. Huppertz: “Automated detection of gray matter malformations using optimized voxel-based morphometry: a systematic approach“ (NeuroImage (2003); 20 (1): 330-343)                                                                                                                                 IF: 7,8

53. B. J. Connemann, J. Kassubek: “Psychiatric hospitalizations among survivors of cancer in childhood or adolescence“ (New England Journal of Medicine (2003); 349 (19): 1868-1869)                                                     IF: 29,6

54. C. Schönfeldt-Lecuona, F. D. Juengling, B. J. Connemann, S. N. Reske, M. Spitzer, J. Kassubek: “Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol“ (Journal of Clinical Psychopharmacology (2004); 24 (1): 97-98)                                   IF: 4,0

55. B. J. Connemann, J. Kassubek: “Komorbidität depressiver Störungen I: Die Rolle von Achse-I- und Achse-II-Störungen“ (Nervenheilkunde (2004); 23: 5-12)                                                                                                              IF: 0,3

56. J. Kassubek, B. J. Connemann: “Komorbidität depressiver Störungen II: Die Rolle von Erkrankungen des zentralen Nervensystems“ (Nervenheilkunde (2004); 23: 116-121)                                                                                       IF: 0,3

57. J. Kassubek, W. Gaus, G. B. Landwehrmeyer: “Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis“ (Neurology (2004); 62 (3): 523-524)                                             IF: 5,2

58. J. Kassubek, F. D. Juengling, T. Kioschies, K. Henkel, J. Karitzky, B. Kramer, D. Ecker, J. Andrich, C. Saft, P. Kraus, A. J. Aschoff, A. C. Ludolph, G. B. Landwehrmeyer: “Topography of cerebral atrophy in early Huntington´s disease: a voxel-based morphometric MRI study“ (Journal of Neurology, Neurosurgery and Psychiatry (2004); 75 (2): 213-220)    IF: 3,0

59. J. Kassubek, G. B. Landwehrmeyer, D. Ecker, F. D. Juengling, R. Muche, S. Schuller, A. Weindl, A. Peinemann: “Global cerebral atrophy in early stages of Huntington´s disease: quantitative MRI study” (NeuroReport (2004); 15 (2): 363-365)                                                                                                 IF: 2,4

60. A.-D. Sperfeld, J. Kassubek, A. C. Ludolph: “Aktuelle Aspekte in der Diagnostik und Therapie der amyotrophen Lateralsklerose“ (Aktuelle Neurologie (2004); 31: 209-215)                                                                                                               IF: 0,3

61. J. Kassubek, G. Hickok, P. Erhard: “Involvement of classical anterior and posterior language areas in sign language production, as investigated by 4 T functional magnetic resonance imaging“ (Neuroscience Letters (2004); 364 (3): 168-172)                                                                                  IF: 2,1

62. R. Korinthenberg, C. Bauer-Scheid, P. Burkart, H. Martens-Le Bouar, J. Kassubek, F. D. Juengling: “18FDG-PET in epilepsies of infantile onset with pharmacoresistant generalised tonic-clonic seizures“ (Epilepsy Research (2004); 60 (1): 53-61)                                                                                                  IF: 2,4

63. A.-D. Sperfeld, J. Kassubek, A. H. Crosby, B. Winner, A. C. Ludolph, I. Uttner, C. O. Hanemann: "Complicated hereditary spastic paraplegia with thin corpus callosum: variation of phenotypic expression over time“ (Journal of Neurology (2004); 251 (10): 1285-1287)                                                                      IF: 3,3

64. T. Els, J. Kassubek, R. Kubalek, J. Klisch: "Diffusion-weighted MRI during early global cerebral hypoxia: a predictor for clinical outcome?" (Acta Neurologica Scandinavica (2004); 110 (6): 361-367)                                                     IF: 1,4

65. C. Schönfeldt-Lecuona, R. W. Freudenmann, H. Tumani, J. Kassubek, B. J. Connemann: “Acute psychosis with a mediastinal carcinoma metastasis“ (Medical Science Monitor (2005); 11 (1): CS6-8)                                                     IF: -

66. F. D. Juengling*, J. Kassubek* [korrespondierender Autor], H.-J. Huppertz, T. Krause, T. Els [* geteilte Erstautorenschaft]: "Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET" (Journal of the Neurological Sciences (2005); 228 (2): 179-184)                                                          IF: 2,4           

67. A.-D. Sperfeld, C. O. Hanemann, A. C. Ludolph, J. Kassubek: "Laryngospasm: an underdiagnosed symptom of X-linked spinobulbar muscular atrophy" (Neurology (2005); 64 (4): 753-754)                         IF: 6,0

68. A.-D. Sperfeld, V. Bretschneider, L. Flaith, A. Unrath, C. O. Hanemann, A. C. Ludolph, J. Kassubek: “MR-pathologic comparison of upper spinal cord in different motor neuron diseases” (European Neurology (2005); 53 (2): 74-77)

                                                                                                                                 IF: 1,3

69. J. Brettschneider, M. Maier, S. Arda, A. Claus, S. D. Süssmuth, J. Kassubek, H. Tumani: "Tau protein level in cerebrospinal fluid is increased in patients with early multiple sclerosis" (Multiple Sclerosis (2005); 11 (3): 261-265)             IF: 2,8

70. J. Kassubek, F. D. Juengling, D. Ecker, G. B. Landwehrmeyer: "Thalamic atrophy in Huntington´s disease co-varies with cognitive performance: a morphometric MRI analysis" (Cerebral Cortex (2005); 15 (6): 846-853)

                                                                                                                                 IF: 5,6

71. H.-P. Müller, I. DeCesaris, M. DeMelis, L. Marzetti, A. Pasquarelli, S. N. Erné, A. C. Ludolph, J. Kassubek: "Open magnetic and electric graphic analysis: comprehensive magnetoencephalographic and functional magnetic resonance imaging in one single software environment" (IEEE Engineering in Medicine and Biology (2005); 24 (3): 109-116)                        IF: 1,3

72. R. Wiest, J. Kassubek, K. Schindler, T. J. Loher, C. Kiefer, L. Mariani, M. Wissmeyer, G. Schroth, J. Mathis, B. Weder, F. D. Juengling: "Comparison of voxel-based 3-D MRI analysis and subtraction ictal SPECT coregistered to MRI in focal epilepsy" (Epilepsy Research (2005); 65 (1-2): 125-133)                 IF: 2,9

73. J. Kassubek, V. Bretschneider, A.-D. Sperfeld: "Corticospinal tract MRI hyperintensity in X-linked Charcot-Marie-Tooth disease" (Journal of Clinical Neuroscience (2005); 12 (5); 588-589)                                                     IF: 0,8           

74. D. Ecker,  U. W. Geisthoff,  M. Juchems, G. Schneider, A. C. Ludolph, J. Kassubek, R. Huber: "Hereditäre hämorrhagische Teleangiektasie – seltene Insultursache mit Behandlungsoption" (Nervenarzt (2005); 76 (8): 980-983)                                                                                                                                       IF: 0,9

75. J. Brettschneider, A. Claus, J. Kassubek, H. Tumani: "Isolated blood-cerebrospinal fluid barrier dysfunction: prevalence and associated diseases" (Journal of Neurology (2005); 252 (9): 1067-1073)                             IF: 3,1

76. J. A. Kress, P. Kühnlein, P. Winter, A. C. Ludolph, J. Kassubek [korrespondierender Autor], U. Müller, A.-D. Sperfeld: „Novel mutation in the ALS2 gene in juvenile amyotrophic lateral sclerosis” (Annals of Neurology (2005); 58 (5): 800-803)                                                                        IF: 8,1

77. H.-J. Huppertz, C. Grimm, S. Fauser, J. Kassubek, I. Mader, A. Hochmuth, J. Spreer, A. Schulze-Bonhage: „Enhanced visualization of blurred gray-white matter junctions in focal cortical dysplasia by voxel-based 3-D MRI analysis” (Epilepsy Research (2005); 67 (1-2): 35-50)                                         IF: 2,9

78. Peinemann, S. Schuller, C. Pohl, T. Jahn, A. Weindl, J. Kassubek: “Executive dysfunction in early stages of Huntington’s disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric study" (Journal of the Neurological Sciences (2005); 239 (1): 11-19)                                                                            IF: 2,4

79. D. Lulé, A. Kurt, R. Jürgens, J. Kassubek, V. Diekmann, E. Kraft, N. Neumann, A. C. Ludolph, N. Birbaumer, S. Anders: "Emotional responding in amyotrophic lateral sclerosis" (Journal of Neurology (2005); 252 (12): 1517-1524)  IF: 3,1

80. J. Kassubek, A. Unrath, H.-J. Huppertz, D. Lulé, T. Ethofer, A.-D. Sperfeld, A. C. Ludolph: "Global brain atrophy and corticospinal tract alterations in ALS, as investigated by voxel-based morphometry of 3-D MRI" (Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders (2005); 6 (4): 213-220)

                                                                                                                                 IF: 1,2

81. A.-D. Sperfeld, A. Baumgartner, J. Kassubek: “Magnetic resonance investigation of the upper spinal cord in pure and complicated hereditary spastic paraparesis” (European Neurology (2005); 54 (4):181-185)IF: 1,3

82. R. Huber, J. Kassubek: „Minor trauma may lead to traumatic internal carotid artery dissection” (Neurocritical Care (2005); 3 (3): 254-256)           IF: 0,5

83. T. Els, E. Oehm, S. Voigt, J. Klisch, A. Hetzel, J. Kassubek: "Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke" (Cerebrovascular Diseases (2006); 21 (1-2): 79-85) IF: 2,3

84. A. Riecker, J. Kassubek, K. Groeschel, W. Grodd, H. Ackermann: "The cerebral control of speech tempo: opposite relationship between speaking rate and BOLD signal changes at striatal and cerebellar structures" (NeuroImage (2006); 29 (1): 46-53)                                                                                                            IF: 5,3

85. I. Uttner, F. M. Mottaghy, H. Schreiber, A. Riecker, A. C. Ludolph, J. Kassubek: "Primary progressive aphasia accompanied by environmental sound agnosia: a neuropsychological, MRI and PET study" (Psychiatry Research Neuroimaging (2006); 146 (2): 191-197)                      IF: 2,7

86. H.-J. Gdynia, J. Kassubek, A.-D. Sperfeld: „Laryngospasm in neurological diseases” (Neurocritical Care (2006); 4 (2); 163-167)                         IF: 0,5

87. A. G. Ludolph, F. D. Juengling, G. Libal, A. C. Ludolph, J. M. Fegert, J. Kassubek: "Grey matter abnormalities in boys with Tourette Syndrome: a 3-D MRI study using optimized voxel-based morphometry" (British Journal of Psychiatry (2006); 188 (5): 484-485)                                              IF: 5,0

88. J. Kassubek, F. D. Juengling, A. G. Ludolph: "Heterogeneity of voxel-based morphometry findings in Tourette syndrome: an effect of age?" (Annals of Neurology (2006); 59 (5): 872-873)                                                      IF: 7,6

89. J. Kassubek, A.-D. Sperfeld, A. Baumgartner, H.-J. Huppertz, A. Riecker, F. D. Juengling: "Brain atrophy in pure and complicated hereditary spastic paraparesis: a quantitative 3-D MRI study" (European Journal of Neurology (2006); 13 (8): 880-886)                                                                       IF: 2,2

90. R. Schüle, T. Holland-Letz, S. Klimpe, J. Kassubek, T. Klopstock, V. Mall, S. Otto, B. Winner, L. Schöls: "The spastic paraplegia rating scale (SPRS): a reliable and valid measure of disease severity" (Neurology (2006); 67 (3): 430-434)                                                                                                             IF: 5,0

91. M. W. Riepe, J. Kassubek, F. Tracik, G. Ebersbach: "Screening for cognitive impairment in Parkinson’s disease - which marker relates to disease severity?" (Journal of Neural Transmission (2006); 113 (10): 1463-1468)                     IF: 2,5

92. K. Henkel, A. Danek, J. Grafman, J. Butman, J. Kassubek: "Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis: a voxel-based morphometry study" (Movement Disorders (2006); 21 (10): 1728-1731)

                                                                                                                                 IF: 2,8

93. A. Unrath, J. Kassubek: "Symptomatic restless leg syndrome after lacunar stroke: a lesion study" (Movement Disorders (2006); 21 (11): 2027-2028)

                                                                                                                                 IF: 2,8

94. C. Beetz, A. O. H. Nygren, J. Schickel, M. Auer-Grumbach, K. Bürk, G. Heide, J. Kassubek, S. Klimpe, T. Klopstock, F. Kreuz, S. Otto, R. Schüle, L. Schöls, A.-D. Sperfeld, O. W. Witte, T. Deufel: "High frequency of partial SPAST deletions in autosomal dominant hereditary spastic paraplegia" (Neurology (2006); 67 (11): 1926-1930)                                                                                                  IF: 5,0

95. J. Brettschneider, A. Petzold, S. D. Süßmuth, G. B. Landwehrmeyer, A. C. Ludolph, J. Kassubek, H. Tumani: "The neurofilament heavy chain NfH(SMI35) in cerebrospinal fluid supports the differential diagnosis of Parkinsonian syndromes" (Movement Disorders (2006); 21 (12): 2224-2227)                IF: 2,8           

96. J. Kassubek: "Parkinsonsyndrom und Demenz" (MMW - Fortschritte der Medizin (2006); 148 (51-52): 36-37)                                                  IF: -

97. E. H. Pinkhardt, L. Tebartz van Elst, A. C Ludolph, J. Kassubek: "Amygdala size in amyotrophic lateral sclerosis without dementia: an in vivo study using MRI volumetry" (BMC Neurology (2006); 6 (1): 48 (1-6)) IF: -

98. A.-D. Sperfeld, A. Unrath, J. Kassubek: "Restless legs syndrome in hereditary spastic paraparesis" (European Neurology (2007); 57 (1): 31-35)                                                                                                                      IF: 1,1

99. M. Mühlau, A. Weindl, A. M. Wohlschläger, C. Gaser, M. Städtler, M Valet, C. Zimmer, J. Kassubek, A. Peinemann: "Voxel-based morphometry indicates relative preservation of the limbic prefrontal cortex in early Huntington Disease" (Journal of Neural Transmission (2007); 114 (3):367-372)              IF: 2,5

100.        H.-P. Müller, A. Unrath, A. C. Ludolph, J. Kassubek: "Preservation of diffusion tensor properties during spatial normalization by use of tensor imaging and fiber tracking on a normal brain database" (Physics in Medicine and Biology (2007); 52 (6): N99-N109)                             IF: 2,7

101.        G. Hirschfeld, A.-D. Sperfeld, J. Kassubek, K. Scharffetter-Kochanek, C. Sunderkötter: "Transiente globale Amnesie (TGA) während einer oralen Arzneimittelexposition" (Hautarzt (2007); 58 (2): 149-152)                   IF: 0,5

102.     J. Kassubek: "Häufige Komorbidität: Fast jeder zweite Parkinsonpatient wird dement" (NeuroTransmitter (2007); 18 (4); 64-65)                             

103. I. Uttner, A. Baumgartner, A.-D. Sperfeld, J. Kassubek: "Cognitive performance in pure and complicated hereditary spastic paraparesis: a neuropsychological and neuroimaging study" (Neuroscience Letters (2007); 419 (2): 158-161)                                                                                                                     

104. D. Lulé, V. Diekmann, S. Anders, J. Kassubek, A. Kübler, A. C. Ludolph, N. Birbaumer: “Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS)” (Journal of Neurology (2007); 254 (4): 519-527)

                                                                                                                                                                          

105. A. Riecker, H. Ackermann, J. Kassubek, B. Herrnberger, C. Steinbrink: "Bilateral language function in callosal agenesis: an fMRI and DTI study" (Journal of Neurology (2007); 254 (4): 528-530)                                                                             

106. M. Sabolek, A. Unrath, A.-D. Sperfeld, B. J. Connemann, J. Kassubek: "Psychotische Störung unter Rofecoxib" (Psychiatrische Praxis (2007); 34 (4): 200-202)                                                                                                                                 

107. M. Mühlau, C. Gaser, A. M. Wohlschläger, A. Weindl, M. Städtler, M Valet, C. Zimmer, J. Kassubek, A. Peinemann: "Striatal gray matter loss in Huntington Disease is leftward biased" (Movement Disorders (2007); 22 (8): 1169-1173)                                                                                                                                                                                          

108. H.-J. Gdynia, A.-D. Sperfeld, L. Flaith, P. Kuehnlein, A. Unrath, A. C. Ludolph, J. Kassubek: "The classification of phenotype characteristics in adult-onset spinal muscular atrophy" (European Neurology (2007); 58 (3): 170-176)                                                                                                                                                   

109. J. Kassubek, S. Braune, T. Büttner, G. Fuchs, W. Greulich, M. Hahne, M. Müngersdorf, I. Reuter: "Dopaminerge Stimulation: orale Applikation mit kontrollierter Freisetzung versus transdermale Applikation" (Aktuelle Neurologie (2007); 34 (Suppl. 1): S31-S32)                                                        

110. H. Ammermann*, J. Kassubek*, M. Lotze, E. Gut, M. Kaps, J. Schmidt, F. A. Rodden, W. Grodd (*geteilte Erstautorenschaft): "MRI brain lesion patterns in patients in anoxia induced vegetative state" (Journal of the Neurological Sciences (2007); 260 (1-2): 65-70)                                               

111. C. Ikonomidou, I. Scheer, T. Wilhelm, F. Juengling, K. Titze, B. Stoever, U. Lehmkuhl, S. Koch, J. Kassubek: "Brain morphology alterations in the basal ganglia and the hypothalamus following prenatal exposure to antiepileptic drugs" (European Journal of Paediatric Neurology (2007); 11 (5): 297-301)

112. J. Kassubek: "Improved screening for a widespread disorder with therapeutic options: restless legs syndrome" (European Journal of Neurology (2007); 14 (9): 951)                                                                                        

113. A. Unrath, A. C. Ludolph, J. Kassubek: "Brain metabolites in definite amyotrophic lateral sclerosis: a longitudinal proton magnetic resonance spectroscopy study" (Journal of Neurology (2007); 254 (8): 1099-1106)

114. R. Viviani, P. Beschoner, T. Jaeckle, P. Hipp, J. Kassubek, B. Schmitz: "The bootstrap and cross-validation in neuroimaging applications: Estimation of the distribution of extrema of random fields for single volume tests, with an application to ADC maps" (Human Brain Mapping (2007); 28 (10): 1075-1088)

115. A. Unrath, F. D. Juengling, M. Schork, J. Kassubek: "Cortical grey matter alterations in idiopathic restless legs syndrome: an optimized voxel-based morphometry study" (Movement Disorders (2007); 22 (12): 1751-1756)                                                                                                                                                                                 

116. J. Kassubek: "Einsatz von Rotigotin bei fortgeschrittener Parkinson-Erkrankung"(Aktuelle Neurologie (2007); (Suppl.) in press)                          

117. D. Lulé, V. Diekmann, J. Kassubek, A. Kurt, N. Birbaumer, A. C. Ludolph, E. Kraft: "Cortical plasticity in amyotrophic lateral sclerosis: motor imagery and function" (Neurorehabilitation and Neural Repair (2007); in press)  

118. J. Kassubek, F. D. Juengling, A.-D. Sperfeld: "Widespread white matter changes in Kennedy Disease: a voxel-based morphometry study" (Journal of Neurology, Neurosurgery and Psychiatry (2007); in press)  

119. A. Unrath, J. Kassubek: "Computer-based 3-D MRI analysis in amyotrophic lateral sclerosis: common and specific factors among studies" (American Journal of Neuroradiology (2007); in press)                             

120. J. Kassubek, F. D. Juengling, A. Baumgartner, A. Unrath, A. C. Ludolph, A.-D. Sperfeld: "Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: a voxel-based morphometric study" (Amyotrophic Lateral Sclerosis (2007); in press)                        

121. J. Kassubek, A.-D. Sperfeld: "Differenzialdiagnostik der spastischen Spinalparalyse" (PsychoNeuro (2007); in press)                                             

122. H.-J. Huppertz, J. Kassubek, D.-M. Altenmüller, T. Breyer, S. Fauser: "Automatic curvilinear reformatting of three-dimensional MRI data of the cerebral cortex" (NeuroImage (2007); in press)                                                                    

123. H. J. Gdynia, T. Müller, A.-D. Sperfeld, P. Kuehnlein, M. Otto, J. Kassubek, A. C. Ludolph: "Severe sensorimotor neuropathy after Intake of highest dosages of vitamin B6" (Neuromuscular Disorders (2007); in press)