Klinisch-wissenschaftliche Schwerpunkte:

Neurodegenerative Erkrankungen

• Demenzerkrankungen (Leiterin der Gedächtnisambulanz Universität Ulm)

Wissenschaftliche Ausbildung

Wissenschaftliches Arbeitsgebiet

Neurodegeneration (Schwerpunkt M. Alzheimer)

• Intrazelluläre Transportmechanismen von APP und Sekretasen
• Funktionelle Interaktionen von Apolopoprotein E und LRP bei M. Alzheimer
• Funktionelle Bildgebung

Auszeichnungen

Posterpreis der Deutschen Gesellschaft für Neurologie 2005

Forschungsförderung

• Landesstiftung Baden - Württemberg
• Universität Ulm
• Alzheimer Forschungsinitiative e.V.
• Hirnliga e.V.
• Heidelberger Akademie der Wissenschaften (WIN-Kolleg)

Lehrqualifikation

Lehr- und Fortbildungsbeauftragte der Abteilung Neurologie.

Publikationen (seit 2000)

Originalarbeiten

Thees S., Neumaier B., Glatting G., von Arnim C.A.F., Reske S.N., Mottaghy F.M. Radiation dosimetry and biodistribution of the amyloid plaque imaging tracer [11C]BTA-1 in humans Nuklearmedizin 2007 in press

Thomas, A.V., Berezovska, O., Hyman, B.T., von Arnim, C.A.F. (2007), Visualizing Interaction of Proteins relevant to Alzheimer's Disease in intact Cells. Methods  in press

von Arnim, C.A.F., Spoelgen, R., Peltan, I.D., Deng, M., Courchesne, S., Koker, M., Matsui, T., Kowa, H., Lichtenthaler, S.F., Irizarry, M.C., Hyman, B.T. (2006) GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J Neurosci 26:9913-9922.

Peltan, I.D., Thomas, A.V., Mikhailenko, I., Strickland, D.K., Hyman, B.T., von Arnim, C.A.F. (2006) Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons. Biochem Biophys Res Commun 349:24-30.

Cao, C., Lawrence, D.A., Li Y., von Arnim C.A.F., Herz J., Su E.J., Makarova A., Hyman B.T., Strickland D.K., Zhang L. (2006) Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. Embo J 25:1860-1870

Spoelgen, R., von Arnim, C.A.F., Peltan, I.D., Thomas, A.V., Koker, M., Deng, M., Andersen, O.M., Willnow, T.E., Hyman, B.T. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein and beta-secretase, BACE J. Neuroscience 26(2): 418-28

von Arnim, C.A.F. *, Verstege, E.*, Etrich, S.M., Riepe, M.W. (2006) Mechanisms of hypoxic tolerance in presymptomatic APP23 transgenic mice Mech ageing and dev., 127(2): 109-14

Koh, Y.H., von Arnim, C.A.F., Hyman, B.T., Tanzi, R.E. and Tesco, G. (2005). BACE is degraded via the lysosomal pathway. J Biol Chem 280, 32499-504.

Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X. et al. (2005). Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 102, 13461-6.

Lleo, A., Waldron, E., von Arnim, C.A.F., Herl, L. Tangredi, M.M., Peltan, I.D., Strickland, D.K., Koo, E.H., Hyman, B.T., Pietrzik, C.U., Berezovska, O. (2005) Low density lipoprotein receptor related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein for g-secretase J Biol Chem 280, 27303-9.

von Arnim, C.A.F.*, Kinoshita, A.*, Peltan, I.D., Tangredi, M.M., Herl, L., Lee, B.M., Spoelgen, R., Hshieh, T.T., Ranganathan, S., Battey, F., Liu, C.-X., Bacskai, B.J., Sever, S., Irizarry, M.C., Strickland, D.K., Hyman, B.T. (2005) The LDL-receptor related protein (LRP) is a novel b-secretase (BACE1) substrate. J. Biol. Chem. 280, 17777-85.

von Arnim, C.A.F. *, Hellweg, R. *, Büchner, M., Huber, R., Riepe, M.W. (2005) Regional selectivity of amyloid mRNA expression and neurotrophins on repetitive inhibition of oxidative phosphorylation J. Neural Transm., 112, 491-8.

von Arnim, C.A.F., Tangredi, M.M., Peltan, I.D., Lee, B.M., Irizarry, M.C., Kinoshita, A., Hyman, B.T. (2004) Demonstration of BACE (b-secretase) phosphorylation and its interaction with GGA1 in cells by Fluorescence lifetime imaging, J. Cell Sci. 117: 5437-5445.

Irizarry, M.C.*, Deng, A.*, Lleo, A., Berezovska, O., von Arnim, C.A.F., Martin-Rehrmann, M., Manelli, A., LaDu, M.J., Hyman, B.T., Rebeck, G.W. (2004) Apolipoprotein E inhibits gamma-secretase cleavage of the amyloid precursor protein. J. Neurochem. 90: 1132-1143

Ranganathan, S., Liu, C.X., Migliorini, M.M., von Arnim, C.A.F., Peltan, I.D., Mikhailenko, I., Hyman, B.T. and Strickland, D.K. (2004) Serine and threonine phosphorylation of the LDL receptor-related protein (LRP) by protein kinase Calpha regulates endocytosis and association with adaptor molecules. J Biol Chem. 279(39): 40536-40544

von Arnim, C.A.F. *, Verstege, E.*, Riepe, M.W. (2004) Strain dependence of receptor regulation on chemical preconditioning in mice hippocampus. Neurosci. Lett. 365, 171-5

Hellweg, R. *, von Arnim, C.A.F. *, Huber, R., Büchne,r M., Riepe, M.W. (2003) Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation Exp. Neurology, 183 (2), 346-354

von Arnim, C.A.F.*, Etrich, S.*, Timmler, M., Riepe, M.W. (2002) Gender-dependent hypoxic tolerance: mediated via gender-specific mechanisms, J Neuroscience Res. 68:84-88

von Arnim, C.A.F., Timmler, M., Ludolph, A.C., Riepe, M.W  (2001) Chemical preconditioning in mice is not mediated by upregulation of nitric oxide synthase isoforms, Neurosci Lett  299:130-134

von Arnim, C.A.F., Timmler, M., Ludolph, A.C., Riepe, M.W. (2000) Adenosine receptor up-regulation: initiated upon preconditioning but not upheld. Neuroreport. 11(6):1223-6.

Übersichtsarbeiten

von Arnim, C.A.F., Ludolph, A.C (2001) Normal and pathological aging of the brain, Fortschr Med. 118(4):165-8.

Buchartikel

von Arnim, C.A.F. Alterung des Zentralnervensystems; in: Neurodegenerative Erkrankungen des Alters, Hrsg.: J. Winkler, A.C. Ludolph; Georg Thieme Verlag, 2004